Novel green synthesis of tin nanoparticles by medicinal plant: Chemical characterization and determination of cytotoxicity, cutaneous wound healing and antioxidant properties

In the present study, tin nanoparticles were green-synthesized using aqueous extract of Foeniculum vulgare leaf extract. The synthesized SnNPs (tin nanoparticles) characterized by analytical techniques including EDX (energy dispersive X-ray), FE-SEM (field emission scanning electron microscopy), XRD (X-ray diffraction), UV–vis and FT-IR (Fourier transform-infrared). cytotoxicity activity was evaluated MTT (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide) assay. formed in a spherical shape range size 26.45–38.53 nm. antioxidant test, IC50 F. vulgare, [email protected] (Sn vulgare) BHT (butylated hydroxytoluene) against DPPH (2,2-diphenyl-1-picrylhydrazyl) free radicals 384, 119 71 µg/mL, respectively. cellular molecular part recent treated cells with assessed assay for 48h about property on normal HUVEC (human umbilical vein endothelial cells) cell line. vivo experiment, ointment significantly decreased (p ≤ 0.01) wound area, total cells, neutrophil lymphocyte notably increased contracture, vessel, hydroxyl proline, hexosamine, hexuronic acid fibrocyte compared to other groups rats. Further clinical trials are necessary confirmation these remedial properties humans.